“I had a great experience with Orlando Hair Clinic. Their customer service is outstanding, and the entire team truly cares about their clients. They take the time to explore every possible option to help you and make sure you feel comfortable and confident throughout the process. What impressed me m…”
“After reading a lot of verified reviews I decided to go with Dr. J at Orlando Hair Clinic. My consultation with Jess was great. The procedure went very well and Jess was very communicative throughout the whole process. Dr. J and Jess are true professionals.”
“I am 1 week post op and things have been going great. During the procedure I got 3000 grafts in the frontal portion and everything went super smooth and as planned. Dr. J made sure I was happy with the position of the hairline before the procedure and Jess has been super helpful from the consultatio…”
Central Florida’s climate creates a unique set of challenges for hair restoration patients. Year-round sun exposure, high humidity, and an active outdoor lifestyle mean that hair loss is highly visible here, and that patients want results that hold up through heat, sweat, and a full social calendar. Orlando’s population is also one of the most diverse in the country, spanning young families, retirees, tourism and healthcare professionals, and a rapidly growing community of patients in their 30s and 40s who are proactively addressing early hair loss before it becomes severe.
ACell hair restoration has emerged as one of the most scientifically grounded adjunctive therapies available to hair transplant patients and to those seeking non-surgical options. ACell uses a porcine-derived extracellular matrix product called MatriStem to create a biologically active scaffold that supports tissue healing, reduces inflammation, and may stimulate dormant hair follicles. When applied during or alongside a hair transplant procedure, it is intended to improve graft survival and accelerate the recovery process.
At Orlando Hair Clinic, patients choose us because Dr. J brings over 25 years of clinical experience and more than 1,000 five-star reviews to every consultation. He is ABIM board-certified, and his approach to ACell therapy reflects his broader commitment to evidence-based medicine. We do not apply every available technology to every patient. We evaluate whether ACell is appropriate for your specific pattern of loss, your scalp health, and your goals before recommending it as part of your plan. Our FUE hair transplant options and Micro FUE procedures can each be enhanced with ACell when clinically appropriate, giving you access to a comprehensive, physician-directed treatment strategy.
of patients in a pilot ACell and PRP trial showed visible clinical improvement in hair density at 6-month follow-up Garg S. | J Cutan Aesthet Surg, 2012
average increase in hair density over baseline observed in patients receiving ECM-augmented biological hair restoration Gentile P et al. | Int J Mol Sci, 2015
ECM scaffolds from urinary bladder matrix consistently promoted site-appropriate tissue regeneration rather than scar formation Badylak SF et al. | Acta Biomater, 2009
graft survival rates in ACell-augmented FUE reported to trend above historical controls in multiple reviewed series Gupta AK and Carviel J | J Cutan Med Surg, 2019
“When a patient sits across from me and asks whether ACell is worth it, I give them an honest answer rather than a rehearsed sales pitch. I have been practicing medicine for more than 25 years, and I have watched regenerative therapies evolve considerably over that time. ACell MatriStem is not a miracle product. What it is, in my clinical view, is a well-studied biological scaffold with real mechanisms of action that can meaningfully support the healing environment around transplanted grafts and existing follicles.
I use ACell selectively. Not every patient needs it, and I will tell you that clearly at your consultation. For patients undergoing FUE hair transplants who want to maximize graft survival, or for patients with diffuse thinning who are not yet surgical candidates and want to support their existing follicles, ACell can be a rational, science-backed addition to the treatment plan. I review the published literature, I stay current on peer-reviewed findings, and I apply that knowledge directly to your case.
What I will not do is overpromise. Hair restoration is a medical specialty, not a marketing exercise. My job is to give you accurate information, set realistic expectations, and use every clinically appropriate tool to help you reach the best possible outcome for your unique hair loss situation.”
Understanding the biology behind ACell helps set realistic expectations and clarifies why it is used as a targeted adjunct rather than a standalone treatment.
ACell MatriStem is a biologically derived extracellular matrix (ECM) product made from porcine urinary bladder matrix. It is available in both powder and sheet forms. In hair restoration, the powder form is most commonly used, either applied topically to the scalp or injected in combination with platelet-rich plasma. The ECM scaffold it provides is rich in structural proteins, growth factors, and signaling molecules that recruit the body's own regenerative cells to the treatment area.
When ACell MatriStem is introduced to the scalp, it acts as a biological scaffold. The ECM material signals local stem cells and progenitor cells to migrate into the area. It modulates the inflammatory response, a critical step in wound healing and graft survival. Rather than triggering scar tissue formation (the typical default healing response), ACell promotes constructive remodeling, a process that more closely resembles regenerative repair.
In the context of a hair transplant, the micro-wounds created during FUE graft harvesting and recipient site creation heal in a more organized, tissue-positive environment. Grafts have access to improved vascularity and a less hostile inflammatory milieu during the critical first days after transplantation. This is why ACell is particularly valuable when combined with our NeoGraft hair transplant and J Graft hair transplant procedures.
Dr. J applies ACell within a physician-led, evidence-guided framework. The decision to use ACell is based on your individual scalp biology and clinical profile, not on upselling additional services. Every step from consultation through follow-up is performed under Dr. J's direct supervision. Patients receive a treatment plan that is specific to their hair loss pattern, not a one-size-fits-all protocol.
In a pilot study evaluating ACell MatriStem combined with PRP for hair loss, patients showed measurable improvement in hair density and tensile strength of hair shafts. Visible clinical improvements were reported in approximately 80% of subjects at 6-month follow-up, with particular benefit noted in patients with androgenetic alopecia.
Sclafani and McCormick demonstrated that porcine extracellular matrix scaffolds, including ACell products, induced migration of follicular stem cells and dermal papilla cells in human scalp tissue models. Constructive remodeling rather than scar formation was observed in treated areas.
Badylak et al. established that extracellular matrix bioscaffolds derived from urinary bladder matrix retain a complex mixture of structural and functional molecules capable of modulating the local stem cell microenvironment. ECM scaffolds consistently promoted site-appropriate tissue remodeling across multiple tissue types.
This review of regenerative medicine in androgenetic alopecia examined multiple biological augmentation strategies. PRP combined with ECM-based scaffolding showed statistically significant improvements in hair count and hair thickness, with average hair density increases of 20 to 30 percent over baseline in responsive patients.
Gupta and Carviel reviewed cell-based and matrix therapies for hair loss, noting that ACell-type ECM products showed the most consistent outcomes when used alongside follicular unit extraction procedures. Graft survival rates in ECM-augmented FUE cases trended higher than historical controls in multiple reported series.
ACell MatriStem is an FDA-cleared medical device indicated for wound care and soft tissue repair. Its application in hair restoration is an evidence-supported off-label clinical use, lawfully practiced when supported by peer-reviewed evidence and physician judgment.
Important Note on Off-Label Use: Off-label use of FDA-cleared devices is a common and lawful clinical practice when supported by scientific evidence and the judgment of a licensed physician. Dr. J reviews the peer-reviewed literature supporting ACell applications in hair restoration and discusses the evidence base with each patient at consultation, so you can make an informed decision about your care.
Dr. J evaluates every patient individually. The following general criteria can help you understand whether ACell may be appropriate for your situation, but a formal consultation is always required before any treatment plan is finalized.
Safety Notice: ACell MatriStem is an FDA-cleared medical device used in wound care and soft tissue repair. Its use in hair restoration represents an off-label clinical application. As with any injectable procedure, risks include infection, allergic response, and localized discomfort. Individual results vary. Dr. J performs a full medical evaluation before recommending ACell therapy, and he will not proceed if contraindications are present. Pricing is available upon consultation only.
From your first conversation with Dr. J to your long-term follow-up, here is exactly what the ACell hair restoration experience looks like at Orlando Hair Clinic.
Dr. J reviews your scalp health, hair loss history, and overall medical background. Photographs are taken at baseline. He discusses whether ACell is appropriate as a standalone treatment or as an adjunct to your FUE hair transplant in Orlando, and explains realistic expectations based on your specific pattern of loss.
Pre-treatment instructions are provided at your consultation. Patients are typically advised to avoid anti-inflammatory medications, alcohol, and blood thinners in the days before treatment. The ACell MatriStem product is prepared for injection according to the clinical protocol. If ACell is being combined with PRP, blood is drawn and processed at this stage.
A topical or local anesthetic is applied to the scalp before injections begin. ACell MatriStem is injected into targeted areas of the scalp - typically zones of active thinning or the recipient and donor zones during an FUE procedure. The injection session itself typically takes 30 to 60 minutes depending on the treatment area and whether additional biologics such as PRP are being applied simultaneously.
Mild redness and scalp tenderness are normal for 24 to 72 hours post-treatment. Most patients return to desk work within one to two days. Strenuous exercise, swimming, and direct sun exposure to the scalp should be avoided for the recovery period Dr. J specifies based on your individual response. A detailed written aftercare instruction sheet is provided before you leave the clinic.
Because ACell works through biological tissue remodeling, results develop gradually. Most patients notice improvements in hair texture, shaft diameter, and reduced breakage between 3 and 6 months after treatment. When used to augment a Micro FUE hair transplant, full results - including the enhanced graft survival benefit - typically become visible over 9 to 12 months.
Dr. J schedules follow-up appointments to document progress using comparative photographs taken at baseline and each visit. Patients with progressive hair loss may benefit from periodic maintenance sessions. Additional sessions are only recommended when clinically justified - Dr. J does not apply a rigid repeat-visit protocol to every patient.
Orlando and the surrounding Central Florida region – including Winter Park, Kissimmee, Lake Mary, Altamonte Springs, Oviedo, and Dr. Phillips – is home to a remarkably active, appearance-conscious population. Whether patients are professionals working in the healthcare and tech corridors along Sand Lake Road, families relocating from the Northeast, or retirees moving into communities throughout Orange and Seminole counties, the desire to maintain a healthy, confident appearance is consistent across demographics. For many of these patients, the combination of Florida’s intense year-round sun exposure and the genetic predisposition to androgenetic alopecia creates an accelerated experience of visible hair thinning – making early, biologically targeted intervention a clinically sound priority.
Central Florida’s climate also plays a role in scalp health that patients often underestimate. Chronic UV exposure, high humidity, and the frequent transitions between air-conditioned interiors and outdoor heat can stress the scalp environment and contribute to follicular inflammation – one of the biological factors that ACell’s anti-inflammatory remodeling properties are specifically designed to address. Patients in Orlando who have experienced premature diffuse thinning, or who have previously undergone a NeoGraft hair transplant in Orlando and want to protect and optimize their results, are among those who benefit most from ACell’s targeted biological support.
Orlando Hair Clinic is conveniently located at 7300 Sand Lake Commons Blvd, Suite 227B, in the heart of the tourist and medical corridor that serves patients across the greater metropolitan area. Patients travel from Windermere, Celebration, Sanford, Clermont, and as far as Tampa and Gainesville for Dr. J’s physician-led approach to hair restoration for women in Orlando and men alike. For Central Florida residents, ACell hair restoration at Orlando Hair Clinic represents access to an advanced regenerative option without the need to travel to a major coastal city.
The following comparison covers the three most commonly asked-about non-surgical options: ACell MatriStem therapy, PRP-only therapy, and low-level laser therapy (LLLT).
Mechanism: Porcine ECM scaffold delivers structural proteins and signaling molecules; recruits stem cells and promotes constructive tissue remodeling. Combined with PRP provides both scaffolding and growth factor stimulation.
Onset of Relief: Visible changes typically 3-6 months; full effect at 6-12 months
Duration of Benefit: Results may be maintained long-term with periodic sessions; underlying loss progression continues without ongoing management
Best For: FUE transplant patients optimizing graft survival; early diffuse thinning; patients wanting biological scaffolding alongside growth factor therapy
Repeatable: Yes – maintenance sessions every 12-18 months as clinically indicated
Mechanism: Autologous platelet-rich plasma delivers concentrated growth factors (PDGF, VEGF, IGF-1) to stimulate follicular activity. No ECM scaffolding component.
Onset of Relief: 3-6 months for noticeable improvement in hair quality and density
Duration of Benefit: Requires ongoing sessions every 3-6 months to maintain results
Best For: Early hair loss patients preferring fully autologous (self-derived) biological stimulation; good standalone or combined with ACell
Repeatable: Yes – frequent maintenance typically required (every 3-6 months)
Mechanism: Photobiomodulation using red or near-infrared light increases cellular ATP production, reduces inflammation, and extends the anagen growth phase. Completely non-injectable.
Onset of Relief: 3-6 months with consistent, compliant use of prescribed session frequency
Duration of Benefit: Dependent on continued device use; results decline when therapy is discontinued
Best For: Patients preferring non-injectable, device-based options; early-stage loss; effective as a complementary tool alongside other treatments
Repeatable: Yes – ongoing use required for sustained benefit
Pricing for ACell hair restoration is not published online because it varies based on the treatment area, whether ACell is being applied as a standalone injectable therapy or integrated into a full FUE hair transplant procedure, and additional patient-specific clinical factors Dr. J evaluates at your consultation. All costs are reviewed transparently and in detail before any treatment plan is confirmed – there are no surprise fees.
Orlando Hair Clinic understands that investing in your hair and confidence is a significant decision. To make treatment accessible, we offer flexible financing through CareCredit and Cherry Pay, allowing patients to choose from a range of payment plan structures that fit their monthly budget. Financing options can be discussed at your consultation or explored in advance by contacting our team directly.
The most important first step is understanding whether ACell is the right clinical choice for your hair loss pattern. We encourage you to schedule a complimentary consultation with Dr. J, where you will receive an honest medical evaluation, a clear explanation of all recommended options, and complete pricing transparency – with no obligation to proceed.
Most patients describe the procedure as uncomfortable rather than painful. Local anesthesia is administered to both the donor and recipient areas before any extraction or implantation begins, and re-administered as needed throughout the session. The injection of the anesthetic itself is the most uncomfortable part for the majority of patients. Post-procedure, mild soreness, tightness, and occasional itching are common for the first several days and are managed with prescribed or recommended medications.
Schedule your complimentary consultation with Dr. J and receive an honest, physician-led evaluation of your hair loss – with a clear plan and transparent pricing. No pressure. No obligation.
The information provided on this page is intended for general educational purposes only and does not constitute medical advice, diagnosis, or treatment. Results from regenerative injection therapies including Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF), Exosome treatments, Autologous Cytokine Rich Serum (ACRS), and Shockwave therapy vary significantly between individuals based on diagnosis, degree of joint degeneration, overall health status, and other clinical factors. No specific outcomes are guaranteed.
Some treatments described on this page may be considered off-label use of biologics or medical devices. Off-label use is a lawful and common clinical practice when supported by peer-reviewed evidence and physician judgment. This page references published peer-reviewed research for informational purposes. Citation of a study does not imply that identical results will be achieved by any individual patient.
Always consult a licensed, board-certified physician before beginning, stopping, or modifying any medical treatment plan. If you are experiencing a medical emergency, call 911 or proceed to your nearest emergency department. Orlando Hair Clinic, 7300 Sand Lake Commons Blvd Ste 227 B, Orlando, FL 32819. Phone: (407) 853-2677. Website: www.orlandohairclinic.com.
